AOP-Wiki

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All Key Events

Showing 1901 to 1921 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

52	Decreased, Calcium influx Short Name Decreased, Calcium influx	1	Cellular	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
51	Inhibition, Ca++ ATPase Short Name Inhibition, Ca++ ATPase	1	Molecular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
50	Increase, Ca++ (intracellular) Short Name Increase, Ca++ (intracellular)	1	Cellular	Nov 29, 2016	Sep 16, 2017	26: Calcium-mediated neuronal ROS production and energy imbalance
49	Reduction, Ca and HCO3 transport to shell gland Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	28: Cyclooxygenase inhibition leading reproductive failure
46	Accumulation, Biological membranes Short Name Accumulation, Biological membranes	1	Cellular	Nov 29, 2016	Sep 16, 2017	35: Narcosis leading to respiratory failure
41	Inhibition, Bile Salt Export Pump (ABCB11) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	27: Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
40	Mitochondrial ATP production, decreased Short Name Mitochondrial ATP production, decreased	1	Cellular	Nov 29, 2016	Oct 16, 2025	7 AOPs 26: Calcium-mediated neuronal ROS production and energy imbalance 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 258: Renal protein alkylation leading to kidney toxicity 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. 590: Increase of intracellular copper leading to cuproptosis via interference with energy metabolism
39	Increased Cholinergic Signaling Short Name Increased Cholinergic Signaling	3	Organ	Nov 29, 2016	Dec 20, 2019	3 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
36	Inhibition, Aromatase Short Name Inhibition, Aromatase	1	Molecular	Nov 29, 2016	Apr 14, 2025	3 AOPs 25: Aromatase inhibition leading to reproductive dysfunction 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
29	Reduction in, Angiogenic sprouts Short Name Reduction in, Angiogenic sprouts	0		Nov 29, 2016	Nov 29, 2016	None
28	Reduction, Angiogenesis Short Name Reduction, Angiogenesis	1	Molecular	Nov 29, 2016	Jul 20, 2022	2 AOPs 43: Disruption of VEGFR Signaling Leading to Developmental Defects 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
26	Antagonism, Androgen receptor Short Name Antagonism, Androgen receptor	1	Molecular	Nov 29, 2016	Mar 20, 2026	9 AOPs 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 345: Androgen receptor (AR) antagonism leading to decreased fertility in females 372: Androgen receptor antagonism leading to testicular cancer 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) 595: Emerging OPFRS reproductive outcome pathway 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
25	Agonism, Androgen receptor Short Name Agonism, Androgen receptor	1	Molecular	Nov 29, 2016	Nov 5, 2024	6 AOPs 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 376: Androgen receptor agonism leading to male-biased sex ratio 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 547: Androgen receptor agonism leading to long anogenital distance in female offspring 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 495: Androgen receptor activation leading to prostate cancer
21	Altered regulation, Alpha hemoglobin Short Name Altered regulation, Alpha hemoglobin	1	Cellular	Nov 29, 2016	Sep 16, 2017	31: Oxidation of iron in hemoglobin leading to hematotoxicity
18	Activation, AhR Short Name Activation, AhR	2	Molecular	Nov 29, 2016	May 31, 2025	22 AOPs 21: Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 57: AhR activation leading to hepatic steatosis 131: Aryl hydrocarbon receptor activation leading to uroporphyria 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 151: AhR activation leading to preeclampsia 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 455: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development 456: Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 494: AhR activation leading to liver fibrosis 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 578: AhR activation leading to cancer progression via immunosuppression 577: AhR activation leading to endometriosis
17	Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway Short Name	0	Molecular	Nov 29, 2016	Aug 19, 2021	2 AOPs 417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
12	Acetylcholinesterase (AchE) Inhibition Short Name AchE Inhibition	1	Cellular	Nov 29, 2016	Apr 29, 2020	7 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 471: Neuron defect induced early behavioral change 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
10	Acetylcholine accumulation in synapses Short Name ACh Synaptic Accumulation	1	Cellular	Nov 29, 2016	Jun 26, 2020	5 AOPs 16: Acetylcholinesterase inhibition leading to acute mortality 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 471: Neuron defect induced early behavioral change
9	Activation, 5HT2c Short Name Activation, 5HT2c	1	Molecular	Nov 29, 2016	Sep 16, 2017	33: Kidney toxicity induced by activation of 5HT2C
8	Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
3	Reduction, 17beta-estradiol synthesis by ovarian granulosa cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	9 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 595: Emerging OPFRS reproductive outcome pathway