Key Event Relationships (KERs)

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Showing 1901 to 1925 of 3102 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2509 1948: Upregulation of ACE2 1738: SARS-CoV-2 cell entry Oct 28, 2021 Oct 28, 2021 None
1238 1172: Increased activation, Nuclear factor kappa B (NF-kB) 1170: Increase, Phenotypic enzyme activity Nov 29, 2016 Dec 3, 2016 None
2309 1172: Increased activation, Nuclear factor kappa B (NF-kB) 1496: Increased proinflammatory mediators Mar 30, 2021 Mar 30, 2021
2431 1172: Increased activation, Nuclear factor kappa B (NF-kB) 87: Release, Cytokine Jul 8, 2021 Jul 8, 2021
2432 1172: Increased activation, Nuclear factor kappa B (NF-kB) 1493: Increased pro-inflammatory mediators Jul 8, 2021 Jul 8, 2021
2612 1172: Increased activation, Nuclear factor kappa B (NF-kB) 112: Antagonism, Estrogen receptor Mar 22, 2022 Aug 27, 2023
1080 1039: Increased activity, beta-2 adrenergic receptor 1040: relaxation, smooth muscle Nov 29, 2016 Dec 3, 2016
2898 2128: Increased adipocyte numbers 2125: Increased fat mass May 4, 2023 May 4, 2023
2899 2127: Increased adipocyte size 2125: Increased fat mass May 4, 2023 May 4, 2023
1612 1449: increased adipogenesis 1447: obesity Jul 24, 2017 Jul 24, 2017
2323 1852: Increased Ang II type 1 receptor (AT1R) 1115: Increase, ROS Apr 10, 2021 Apr 10, 2021
2066 1752: Increased AngII 1743: Increase plasma Ang II Mar 17, 2020 Mar 17, 2020 None
2298 1752: Increased AngII 1849: Impaired gustatory nerve Mar 28, 2021 Mar 28, 2021 None
2300 1752: Increased AngII 1496: Increased proinflammatory mediators Mar 28, 2021 Mar 28, 2021 None
2317 1752: Increased AngII 1856: Sodium inhibition, Sweet enhancement Apr 10, 2021 Apr 10, 2021
2327 1752: Increased AngII 1852: Increased Ang II type 1 receptor (AT1R) Apr 10, 2021 Apr 10, 2021
2593 1752: Increased AngII 1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) Mar 3, 2022 Mar 3, 2022
1647 496: Decreased Leydig Cells 413: Reduction, Testosterone synthesis in Leydig cells Aug 11, 2017 Aug 11, 2017
2030 1722: Increased blood CCK level 1723: Increased acinar cell exocrine secretion Jan 8, 2020 Jan 8, 2020
1955 1663: brain Homocysteine level increases 1664: Neuronal dysfunctions induction Jun 14, 2019 Jun 14, 2019 None
1579 1433: Increased CGRP 1223: Increased Airway Hyper-responsiveness,Cough, Dyspnea Jun 23, 2017 Jun 23, 2017 None
1580 1433: Increased CGRP 1343: Increase, hypertension Jun 23, 2017 Jun 23, 2017 None
1586 1433: Increased CGRP 1225: Leukocyte infiltration Jun 23, 2017 Jun 23, 2017 None
1587 1433: Increased CGRP 1226: Respiratory irritability Jun 27, 2017 Jun 27, 2017
51 39: Increased Cholinergic Signaling 360: Decrease, Population growth rate Nov 29, 2016 Dec 3, 2016 None