AOP-Wiki

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All Key Events

Showing 1001 to 1025 of 1921 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1372	Increase, bicarbonate Short Name Increase, bicarbonate	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1371	Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Short Name	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1370	Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Short Name Activation, PTGS-2	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1369	Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Short Name Activation, PTGS-1	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1368	Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Short Name Inhibition, PTGS-1	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1367	Inhibit, gastric ulcer formation Short Name Inhibit, gastric ulcer formation	0	Organ	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1366	Decrease, Oogenesis Short Name Decrease, Oogenesis	0	Organ	Apr 15, 2017	Apr 30, 2020	9 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1365	Increase, Apoptosis Short Name Increase, Apoptosis	0	Cellular	Apr 15, 2017	Apr 15, 2017	6 AOPs 322: Alkylation of DNA leading to reduced sperm count 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 330: Excessive reactive oxygen species production leading to mortality (4) 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1363	Increased, epilepsy Short Name Increased, epilepsy	0	Individual	Apr 14, 2017	Jun 2, 2017	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy 471: Neuron defect induced early behavioral change
1362	Increased, hippocampal hyperdepolarization Short Name	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1361	Increase, GABA Short Name Increase, GABA	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1360	Activate, presynaptic neuron 2 Short Name Activate, presynaptic neuron 2	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1359	Activate, GABA-A receptor Short Name Activate, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1358	Repress, GABA-A receptor Short Name Repress, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1357	Increased, RDX dose Short Name Increased, RDX dose	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1356	Inactive, membrane depolarization Short Name Inactive, membrane depolarization	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1355	Activated, membrane depolarization Short Name Activated, membrane depolarization	0	Cellular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1354	Treat, carbamazepine Short Name Treat, carbamazepine	0	Molecular	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1353	Binding to voltage-gated sodium channel Short Name Binding to VGSC	1	Molecular	Apr 14, 2017	Jul 31, 2024	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1352	Activated, voltage-gated sodium channel Short Name Activated, voltage-gated sodium channel	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1351	Activated, NMDA receptor Short Name Activated, NMDA receptor	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1350	Increased, glutamate Short Name Increased, glutamate	1	Molecular	Apr 14, 2017	Oct 11, 2021	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
1349	Activated, presynaptic neuron 1 Short Name Activated, presynaptic neuron 1	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 471: Neuron defect induced early behavioral change
1348	Increase, seizure Short Name Increase, seizure	0	Individual	Apr 14, 2017	Apr 14, 2017	3 AOPs 215: Molecular events lead to epilepsy 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 471: Neuron defect induced early behavioral change
1347	Decreased, extracellular serotonin Short Name Decreased, extracellular serotonin	0	Molecular	Apr 14, 2017	May 31, 2017	7 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension