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Showing 1251 to 1275 of 3185 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

889	869: Increase, Respiratory or Squamous Metaplasia	870: Increase, Cell Proliferation	Nov 29, 2016	Dec 1, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
280	252: Increase, Renal pathology due to VTG deposition	339: Altered, Larval development	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
3258	252: Increase, Renal pathology due to VTG deposition	351: Increased Mortality	Jun 24, 2024	Jun 24, 2024	1 AOP 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
3730	2406: Increase, Regenerative nodule formation	2407: Increase, Cirrhosis	Feb 10, 2026	Feb 10, 2026	6 AOPs 624: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction 625: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
797	795: Increase, Regenerative cell proliferation (urothelial cells)	796: Increase, Hyperplasia (urothelial)	Nov 29, 2016	Dec 3, 2016	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
760	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	767: Increase, Hyperplasia (renal tubular cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
785	710: Increase, Regenerative cell proliferation (tubular epithelial cells)	784: Increase, Hyperplasia (tubular epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
727	734: Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)	735: Increase, Hyperplasia (terminal bronchiolar cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
789	787: Increase, Regenerative cell proliferation (hepatocytes)	774: Increase, Preneoplastic foci (hepatocytes)	Nov 29, 2016	Dec 3, 2016	1 AOP 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
782	781: Increase, Regenerative cell proliferation (forestomach epithelial cells)	782: Increase, Hyperplasia (forestomach epithelial cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
779	778: Increase, Regenerative cell proliferation (corneal cells)	779: Increase, Papillomas/carcinomas (squamous cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
1696	1115: Increase, ROS	1491: increased, oncotic necrosis	Nov 14, 2017	Nov 14, 2017	1 AOP 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1965	1115: Increase, ROS	1669: Increased, DNA damage and mutation	Jul 3, 2019	Jul 3, 2019	2 AOPs 303: Frustrated phagocytosis-induced lung cancer 409: Frustrated phagocytosis leads to malignant mesothelioma
2009	1115: Increase, ROS	1392: Increase, Oxidative Stress	Dec 3, 2019	Jun 23, 2026	27 AOPs 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 521: Essential element imbalance leads to reproductive failure via oxidative stress 186: unknown MIE leading to renal failure and mortality 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 462: Activation of reactive oxygen species leading the atherosclerosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis 26: Calcium-mediated neuronal ROS production and energy imbalance 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. 331: Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 595: Emerging OPFRS reproductive outcome pathway 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 472: DNA adduct formation leading to kidney failure 324: Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 325: Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death 326: Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Increase in reactive oxygen species leading to growth inhibition via protein oxidation and cell death 647: ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response 636: Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS)
2033	1115: Increase, ROS	1648: β-catenin activation	Jan 19, 2020	Jan 19, 2020	None
2320	1115: Increase, ROS	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
2324	1115: Increase, ROS	1501: Increase, ECM deposition	Apr 10, 2021	Apr 10, 2021	1 AOP 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
2328	1115: Increase, ROS	1855: Increased Sodium-sensitive hypertension	Apr 10, 2021	Apr 10, 2021	1 AOP 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
2460	1115: Increase, ROS	1445: Increase, LPO	Aug 5, 2021	Apr 11, 2024	4 AOPs 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 329: Excessive reactive oxygen species production leading to mortality (3)
2549	1115: Increase, ROS	1861: D1 protein deactivation	Jan 21, 2022	Jan 21, 2022	1 AOP 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
2550	1115: Increase, ROS	1770: Decrease, MMP	Jan 21, 2022	Jan 21, 2022	2 AOPs 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 328: Excessive reactive oxygen species production leading to mortality (2)
2594	1115: Increase, ROS	68: Increase, Collagen accumulation	Mar 3, 2022	Mar 3, 2022	None
2660	1115: Increase, ROS	2006: Secondary genotoxicity	May 25, 2022	May 25, 2022	1 AOP 451: Interaction with lung resident cell membrane components leads to lung cancer
2966	1115: Increase, ROS	1262: Apoptosis	Jul 18, 2023	Apr 11, 2024	2 AOPs 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
3092	1115: Increase, ROS	233: Decreased, PPAR-gamma activation	Oct 18, 2023	Oct 19, 2023	1 AOP 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway

Key Event Relationships (KERs)

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